Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease
نویسندگان
چکیده
A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients' cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.
منابع مشابه
The effect of green tea consumption on oxidative stress markers and cognitive function in patients with Alzheimer’s disease: A prospective intervention study
Background: Alzheimer’s disease (AD) is the most prevalent degenerative disorder of the brain among elderly individuals. Many studies indicate that oxidative stress is an important pathogenic factor which involves oxidizing macromolecules such as DNA, lipids, and proteins in AD. Green tea is a rich source of antioxidant compounds that can remove radical oxygen species. The purpose of this...
متن کاملThe Effect of High Intensity Interval Training (HIIT) with Omega-3 Consumption on Plasma Level of Bdnf in Non-Athletes Male Adolescents
Introduction: The prevalence of overweight and obesity in adolescents and adults worldwide is known to be a critical health determinant that begins in childhood and continues most of the time until adulthood. Brain Drived Nurotrophic Factor Growth Factor (BDNF) stimulates and activates neuronal stem cells that proliferates and differentiates neurons, and is essential for the regulation of neuro...
متن کاملThe Effect of Multi Sensory Stimulation (MSS) on Cognitive Disturbances and Quality of Life of Male Patients with Alzheimer’s Disease
Objectives: Alzheimer’s disease causes many negative effects on the individualchr('39')s physical, psychological and cognitive conditions. The multi sensory stimulation helps the patients to improve their physical, psychological and cognitive conditions. The aim of this study is to determine the effect of multi sensory stimulation on cognitive status and quality of life of the patients with Alz...
متن کاملThe Effect of Endurance Training and Saffron Extract on Plasma Levels of Interleukin 17 and 18 in Alzheimer’s Rats by Trimethyltin Chloride
Objective: The Pathological symptoms of Alzheimer’s disease and the degeneration of nerve cells cause inflammation in these patients. This study aimed to investigate the effect of endurance training and saffron extract on the plasma levels of interleukin 17 and 18 in Alzheimer’s rats by trimethyltin chloride. Methods: This experimental study was conducted on 32 male Sprague-Dawley rats weighi...
متن کاملCognitive Rehabilitation An Effective Intervention to Decrease the Cognitive Deficits in Older Adults With Alzheimer Disease
Objectives: The aim of present study was to investigate the effect of cognitive rehabilitation, a new and non-pharmacological approach to reduce memory and other cognitive deficits in Alzheimer's disease. Methods & Materials: This study was a quasi-experimental research, in singlesubject study-with control group- and based on an A-B design. That was conducted in two groups of control and exp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 57 شماره
صفحات -
تاریخ انتشار 2017